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Home | Max Planck Institute for Medical Research - The institute was opened in 1930 as the Kaiser Wilhelm Institute for Medical Research, and was re-founded as a Max Planck Institute in 1948. Its original goal was to apply the methods of physics and chemistry to basic medical research, and it included departments of Chemistry, Physiology, and Biophysics. In the 1960s, new developments in biology were reflected with the establishment of the Department of Molecular Biology. Toward the end of the 1980s and during the 1990s, investigations began into the specific functions of muscle and nerve cells. New departments were established in Cell Physiology (1989), Molecular Cell Research (1992-1999), Molecular Neurobiology (1995), Biomedical Optics (1999) and Biomolecular Mechanisms (2002). The independent junior research groups for Ion Channel Structure (1997-2003) and Developmental Genetics of the nervous System (1999) were also founded. Since its foundation, five Nobel Prizewinners have worked at the institute: Meyerhof (Physiology), Kuhn (Chemistry), Bothe (Physics), Mößbauer (Physics) and Sakmann (Physiology or Medicine). The institute currently has three departments and two independent junior research groups. The Department of Molecular Neurobiology focuses on the analysis and altering of mouse genes that are responsible for rapid signaling in the brain; the purpose is to investigate which brain capacities are inherited and which are learned. The Department of Biomedical Optics studies the activity of groups of nerve cells in tissue preparations and in laboratory animals with the use and continued development of multiquantum microscopy. The research in the Department of Biomolecular Mechanisms is aimed at establishing the molecular basis of model reactions, using the methods of biophysics and structural biology.

  • https://www.mpimf-heidelberg.mpg.de/emeritus_groups/biophysics Part 1 | Max Planck Institute for Medical Research - A primary aim of the Department of Biophysics since its foundation in 1968 has been to understand in physiochemical terms the molecular mechanism by which muscles produce force. Muscle contraction involves the cyclic interaction of the proteins myosin and actin, often pictured as the rowing of the myosin and actin filaments past each other, using the hydrolysis of ATP as a source of energy. We study the structures of actin and myosin at atomic and near-atomic resolution by protein crystallography, electron microscopy and X-ray fibre diffraction. As a supplementary technique for studying mobility we also use NMR. We study myosins from various sources and with a varity of bound nucleotide analogues, also in combination with site-directed mutagenesis. A biochemistry group which specializes in the expression of proteins in the cellular slime mould dictyostelium uses enzyme kinetics and in vitro motility assays to guage the effects of mutagenesis. The most interesting cases are then analysed by x-ray crystallography. This project is part of an international collaboration. The last two years have seen dramatic progress in our understanding of the molecular basis of muscle contraction and indeed we now have considerable understanding of the processes involved in myosin-based motility. The crystallography goup studies other proteins as well, in particular on those which, like myosin, involve the processing of nucleotides.

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